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KMID : 0376219810180010035
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Chonnam Medical Journal
1981 Volume.18 No. 1 p.35 ~ p.44
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Experimental Studies on Positional Nystagmus Caused by Anesthetic Agents
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金在浹/Kim, Jeh Hyub
李鐘銀/朴炳林/金盛男/Lee, Jongeun/Park, Byung Rim/Kim, Sung Nam
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Abstract
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In animals with binocular (cats) and monocular vision (rabbits and goats), alcohol (1-2g/kg) or ketamine (5-7 mg/kg was injected intravenously and reflex reactions of the bilateral eyeballs in response to the positional changes were observed in terms of nystagmography. The positional changes were given by passive rotation of the head to right side down or left side down position. Experimental results were as follows.
1. In cats positional nystagmus was elicited after administration of alcohol. Depending upon the direction of the head rotation, the nystagmus appeared to be specific in that direction. In the bilateral eyeballs, the nystagmus were noticed to be identical in their direction and the fast phases of the nystagmus were oriented downwards.
2. In rabbits and goats, similar positional nystagmus was also elicited after administration of alcohol or ketamine. In these animals with monocular vision, however nystagmic patterns of the bilateral eyeballs were contradictory in their directions.
3. In rabbits, positional nystagmus could not be elicited when the bilateral semicircular canals, which can be easily exposed, were selectively destroyed by surgical dissection.
Above experimental results indicate that the administration of anesthetic agents, particularly alcohol or ketamine, causes positional nystagmus in the test animals. The observations made in cats suggest that the direction of positional nystagmus (fast phase) is in accord with the gravitational direction. However, in the monocular vision animals, the same conclusion was not supported by the experimental findings. The experimental evidence also indicates that the semicircular canal system, rather than the otolith organs play a major role in reflex elicitation of positional nystagmus in these animals.
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